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Plant-derived bioactive compounds exhibit significant therapeutic potential, including antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. However, their clinical application is often limited by poor solubility, low bioavailability, rapid metabolism, and instability. Nanotechnology-based delivery systems such as nanoparticles, liposomes, niosomes, and nanoemulsions offer effective solutions by enhancing stability, bioavailability, controlled release, and targeted delivery. This editorial highlights the role of nanoformulations in overcoming pharmacokinetic limitations and advancing the therapeutic efficacy of phytochemicals.