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Reviews in Pharmaceutical Sciences

ISSN: 3139-4191

Big Science Publishers LLP (registered under section 12(1) of the LLP act 2008) is a fully open access non-annual journal, publish high quality science-based articles. Big Science Publishers also guide the young budding researchers, UG/PG students and scholars and other academic professional who wants to learn the manuscript writing.

Reviews in Pharmaceutical Sciences Cover

Reviews in Pharmaceutical Sciences

Big Science Publishers LLP (registered under section 12(1) of the LLP act 2008) is a fully open access non-annual journal, publish high quality science-based articles. Big Science Publishers also guide the young budding researchers, UG/PG students and scholars and other academic professional who wants to learn the manuscript writing.

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A Comprehensive Review on the Role of Vitamin D in the Amygdala and Hippocampus in Relation to Synaptic Plasticity, Cognitive Function, and Emotional Integration

Authors

Brahmaiahchari Rangachari1 , Rajesh Thangarajan2 , Mustafa Rehmatulla Batliwala3 , Ashok Gnanasekaran4 , Ratnarajan thivakulan5 , Pugazhandhi Bakthavachalam6, ✲
Volume 1 , Issue 2 , Oct 2025 , Pages 01-15
Corresponding author

Pugazhandhi Bakthavachalam

Open Access
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. https://creativecommons.org/licenses/by/4.0/

Abstract

Vitamin D, a fat-soluble prohormone, is crucial for calcium homeostasis and bone health. Emerging evidence suggests its broader influence on brain function, particularly synaptic plasticity, cognitive processes, and emotional regulation. This review aims to comprehensively examine the current literature on the role of vitamin D in these crucial aspects of brain function, with a focus on its interplay with the amygdala and hippocampus. We conducted a thorough search of relevant databases, including PubMed, Scopus, and Web of Science, using a combination of keywords related to vitamin D, synaptic plasticity, cognitive function, emotional integration, amygdala, and hippocampus. Inclusion and exclusion criteria were applied to select studies that met specific methodological and quality standards. The results of the review highlight the potential mechanisms through which vitamin D may influence synaptic plasticity, including its effects on neurogenesis, dendritic spine density, and neurotransmitter release. Furthermore, the review explores the association between vitamin D status and cognitive function, including memory, learning, and executive function, as well as emotional processing and regulation. The discussion focuses on the potential clinical implications of these findings, including the potential use of vitamin D supplementation to improve cognitive function, emotional well-being, and mitigate the risk of neurodegenerative diseases. Finally, the conclusion summarizes the key findings of the review and identifies areas for future research to further elucidate the role of vitamin D in brain function and its interplay with the amygdala and hippocampus.

Subject

Pharmacy

History

Received: 2025-12-12
Accepted: 2025-12-26
Available Online: 2025-12-31T00:00:00Z

Keywords

Vitamin D synaptic plasticity Amygdala Hippocampus cognitive function emotional integration

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Journal
Journal Reviews in Pharmaceutical Sciences
Volume Volume 1
Issue Issue 2
Year 2025

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