Big Science
Publishers
Serving Towards Science
Big Science
Publishers
Serving Towards Science
Big Science
Publishers
Serving Towards Science
ISSN: 3139-4191
Big Science Publishers LLP (registered under section 12(1) of the LLP act 2008) is a fully open access non-annual journal, publish high quality science-based articles. Big Science Publishers also guide the young budding researchers, UG/PG students and scholars and other academic professional who wants to learn the manuscript writing.
Big Science Publishers LLP (registered under section 12(1) of the LLP act 2008) is a fully open access non-annual journal, publish high quality science-based articles. Big Science Publishers also guide the young budding researchers, UG/PG students and scholars and other academic professional who wants to learn the manuscript writing.
Volume 2, Issue 3, Pages 49-53
For many years, the Paxinos and Watson stereotaxic atlas has been essential to accuracy in rodent neurosurgery. However, inter-individual anatomical variability in Wistar rats, which is impacted by age, weight, and strain substructures, commonly leads to electrode or cannula misplacement. This narrative research explores the paradigm shift from atlas-based “blind” surgery to tailored, image-guided planning using clinical-grade MRI and Micro-CT. We look at how 3D-segmentation helps identify target nuclei (such the Subthalamic Nucleus), how this enhances surgical results, and how DICOM data is transformed into stereotaxic coordinates. We show that pre-operative imaging lowers animal attrition and improves the translational validity of neurological models by integrating clinical radiography and preclinical surgery.
Wistar rats, Stereotaxic surgery, MRI, Micro-CT, Surgical planning, Neurosurgery, Image-guided surgery.
Submission 21 August 2026
Published 05 September 2026
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. (https://creativecommons.org/licenses/by/4.0/).
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